AustralieFrV1, Main, Exploration, bibRecord, 009C89

Powerful prognostic stratification by [18F] fluorodeoxyglucose positron emission tomography in patients with metastatic breast cancer treated with high-dose chemotherapy

Identifieur interne : 009C89 ( Main/Exploration ); précédent : 009C88; suivant : 009C90

Powerful prognostic stratification by [18F] fluorodeoxyglucose positron emission tomography in patients with metastatic breast cancer treated with high-dose chemotherapy

Auteurs : Florent Cachin [Australie, France] ; H. Miles Prince ; Annette Hogg ; Robert E. Ware ; Rodney J. Hicks

Source :

Journal of clinical oncology [ 0732-183X ] ; 2006.

RBID : Pascal:06-0344914

Descripteurs français

Pascal (Inist)
- Tomoscintigraphie, Pronostic, Glucose(2-désoxy-2-fluor), Métastase, Tomographie émission positon, Homme, Chimiothérapie, Stade avancé, Traitement, Dose forte, Cancérologie, Cancer sein.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- 2-deoxy-2-fluoroglucose, Advanced stage, Breast cancer, Cancerology, Chemotherapy, Emission tomography, High dose, Human, Metastasis, Positron emission tomography, Prognosis, Treatment.

Abstract

Purpose This study examines the use of [¹⁸F]fluorodeoxyglucose positron emission tomography (FDG-PET) for the evaluation of the therapeutic response for patients treated with high-dose chemotherapy (HDC) with autologous stem cell transplantation for metastatic breast cancer (MBC) focusing on prognostic stratification. Patients and Methods Forty-seven patients with MBC were treated with a maximum of three cycles of HDC. Therapeutic response was assessed with conventional imaging (CImg; including a computed tomography in all cases and ultrasound, mammography, and bone scanning as clinically indicated) and by FDG-PET study performed after the last cycle of HDC. Parameters analyzed for predicting survival were FDG-PET and CImg results, pattern of disease, prior treatment, and HDC regimen. Results Complete responses were observed in 16 patients (37%) with CImg and 34 patients (72%) with FDG-PET. The FDG-PET result was the most powerful and independent predictor of survival; patients with a negative post-treatment FDG-PET had a longer median survival than patients with a positive FDG-PET (24 months v 10 months; P <.001). By multivariate analysis the relative risk (RR) of death was higher in patients with FDG-PET-positive disease (RR, 5.3), prior anthracycline treatment (RR, 3.3), or with visceral metastasis (RR, 2.4). Conclusion A single FDG-PET study performed after completion of HDC for MBC can powerfully stratify for survival. This may have implications for how we should assess outcome after conventional-dose therapy for MBC and warrants additional study.

Affiliations:

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Le document en format XML

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<term>Breast cancer</term>
<term>Cancerology</term>
<term>Chemotherapy</term>
<term>Emission tomography</term>
<term>High dose</term>
<term>Human</term>
<term>Metastasis</term>
<term>Positron emission tomography</term>
<term>Prognosis</term>
<term>Treatment</term>
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<term>Pronostic</term>
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<term>Métastase</term>
<term>Tomographie émission positon</term>
<term>Homme</term>
<term>Chimiothérapie</term>
<term>Stade avancé</term>
<term>Traitement</term>
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<front><div type="abstract" xml:lang="en">Purpose This study examines the use of [<sup>18</sup>
F]fluorodeoxyglucose positron emission tomography (FDG-PET) for the evaluation of the therapeutic response for patients treated with high-dose chemotherapy (HDC) with autologous stem cell transplantation for metastatic breast cancer (MBC) focusing on prognostic stratification. Patients and Methods Forty-seven patients with MBC were treated with a maximum of three cycles of HDC. Therapeutic response was assessed with conventional imaging (CImg; including a computed tomography in all cases and ultrasound, mammography, and bone scanning as clinically indicated) and by FDG-PET study performed after the last cycle of HDC. Parameters analyzed for predicting survival were FDG-PET and CImg results, pattern of disease, prior treatment, and HDC regimen. Results Complete responses were observed in 16 patients (37%) with CImg and 34 patients (72%) with FDG-PET. The FDG-PET result was the most powerful and independent predictor of survival; patients with a negative post-treatment FDG-PET had a longer median survival than patients with a positive FDG-PET (24 months v 10 months; P <.001). By multivariate analysis the relative risk (RR) of death was higher in patients with FDG-PET-positive disease (RR, 5.3), prior anthracycline treatment (RR, 3.3), or with visceral metastasis (RR, 2.4). Conclusion A single FDG-PET study performed after completion of HDC for MBC can powerfully stratify for survival. This may have implications for how we should assess outcome after conventional-dose therapy for MBC and warrants additional study.</div>
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<country name="Australie"><region name="Victoria (État)"><name sortKey="Cachin, Florent" sort="Cachin, Florent" uniqKey="Cachin F" first="Florent" last="Cachin">Florent Cachin</name>
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Powerful prognostic stratification by [18F] fluorodeoxyglucose positron emission tomography in patients with metastatic breast cancer treated with high-dose chemotherapy

Powerful prognostic stratification by [18F] fluorodeoxyglucose positron emission tomography in patients with metastatic breast cancer treated with high-dose chemotherapy

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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Pour manipuler ce document sous Unix (Dilib)

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